MP69-10 TRENDS IN STAGE I NON-SEMINOMATOUS GERM CELL TUMORS IN THE UNITED STATES

The management of low-stage non-seminomatous germ cell tumors

The prognosis of patients with stage I non-seminomatous germ cell tumors is in general very good. However, a large number of patients relapse with metastatic disease after orchidectomy Therefore, adjuvant treatment, in the form of either chemotherapy or retroperitoneal dissection is recommended, although active surveillance has been found to be as good a way of treating these patients with over...

Differential Akt signalling in non-seminomatous testicular germ cell tumors.

AIM To investigate the protein kinase B (Akt) signalling proteins phosphatase and tensin homolog (PTEN), phosphorylated-Akt (p-Akt) and cyclin-dependent kinase inhibitor 1B (p27(Kip1)) in non-seminomatous germ cell tumors (NST) with a view to future investigative approaches. MATERIALS AND METHODS The expressions of PTEN, p-Akt and p27(Kip1) were immunohistochemically assessed in 17 teratomas,...

Clinical outcomes in patients with stage I non-seminomatous germ cell cancer.

This study assesses the long-term outcomes in Han Chinese patients with clinical stage I non-seminomatous germ cell testicular cancer (CSI NSGCT) treated with surveillance, retroperitoneal lymph node dissection (RPLND) and adjuvant chemotherapy. We retrospectively evaluated 89 patients with a mean age of 26.5 years. After orchiectomy, 37 patients were treated with surveillance, 34 underwent RPL...

Multicentre risk-adapted management for stage I non-seminomatous germ cell tumours.

BACKGROUND The Spanish Germ Cell Group is composed of 60 centres. Our challenge was to define a surveillance protocol that would be safe and suitable regardless of population size or geographic coverage. METHODS From January 1994 to January 2004, 589 patients with stage I non-seminomatous germ cell tumours entered a risk-adapted surveillance protocol after orchiectomy. Patients with vascular ...

The Role of Surgery in the Management of Recurrent or Persistent Non-seminomatous Germ Cell Tumors